Fri Jan 09 2026

40 articles - From Friday Jan 02 2026 to Friday Jan 09 2026

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Liver Transpl
Living liver donor safety: Intraoperative considerations in living liver donation guidelines from the ILTS-iLDLT group consensus conference 2025.

Working Group II focused on intraoperative monitoring, fluid and ventilation strategies, surgical techniques for vascular and biliary division, surgeon and center specific experience, and intraoperative crises planning. These guidelines aim to support both established and emerging LDLT teams to ensure high-quality and safe intraoperative care for the LLD.

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Meta-analysis

meta-analyses and systematic reviews

Am J Clin Nutr
Comparison of blood lipid responses to high polyunsaturated fatty acid compared with high monounsaturated fatty acid dietary interventions: a systematic review and meta-analysis.

High PUFA diets have a small, but significant, advantage for lowering blood lipids compared with high MUFA diets and may be a valuable strategy for improving blood lipids in some populations.

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Impact of maternal diet on microbiota and health during pregnancy: a systematic review and correlational meta-analysis.

This systematic review found that specific dietary components, particularly fiber, omega-3 fatty acids, and micronutrients, were associated with differences in maternal gut microbiota, with potential relevance to metabolic outcomes such as GDM, obesity, and hypertensive disorders of pregnancy. Meta-analytic results indicate that maternal health status significantly moderated the associations between dietary fat and protein intake and microbial taxa, suggesting that precision nutrition interventions warrant evaluation in metabolically at-risk populations. This study was registered in PROSPERO as CRD420251085137.

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Liver Transpl
Stereotactic body radiation therapy as bridging or downstaging therapy for hepatocellular carcinoma in liver transplant candidates: A systematic review and meta-analysis.

SBRT is a safe and effective bridging or downstaging therapy for HCC patients awaiting LT.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr
Association between serum 25-hydroxyvitamin D status and respiratory tract infections requiring hospital admission: unmatched case-control analysis of ethnic groups from the UK Biobank cohort.

Serum 25(OH)D status below 15 nmol/L is associated with 33% higher HR for RTI hospitalisation among UK adults, compared with ≥ 75 nmol/L. Further studies are warranted to validate these findings and explore the mechanisms underlying the association between vitamin D status and RTIs in different ethnic groups.

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Comparing a diet-wide panel of biomarkers of food intake in whole blood and 24-hour urine and self-reported with known dietary intakes: randomized feeding trial of three 48-hour interventions.

We identified some previously reported associations between foods and proposed biomarkers, but not all, outlining the need for assessing dietary biomarkers across a range of study designs including food intakes within realistic ranges.

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Consuming an unprocessed diet reduces energy intake: A post-hoc analysis of an RCT reveals a role for human 'nutritional intelligence'.

Unprocessed meals may reduce energy intake because (1) they have a less balanced carbohydrate-fat blend; and (2) they promote a form of nutritional intelligence whereby a compromise is struck between consuming calories and consuming micronutrients, which we refer to as "micronutrient deleveraging." Clinical trial registry number and website where it was obtained The original study protocol was approved by the Institutional Review Board of the National Institute of Diabetes & Digestive & Kidney Diseases (ClinicalTrials.gov Identifier NCT03407053, 2018-01-20).

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Diet quality and nutritional adequacy during a 2-year calorie restriction intervention: the CALERIE™ 2 trial.

Diet quality improved and nutritional adequacy was maintained during a 2 y moderate CR intervention designed to enhance healthspan and comprised of comprehensive nutrition counseling among healthy adults without obesity. Clinical trial registry NCT00427193. Registered 1/24/2007.

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Prognostic value of adiposity indices in anticoagulated patients with atrial fibrillation: The prospective Murcia AF Project III cohort.

In anticoagulated AF patients, the C-index demonstrated strongest and consistent prognostic value among al adiposity indices. Its integration into conventional risk scores may enhance risk stratification in this high-risk population.

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The Sweet Tooth Trial: A Parallel Randomized Controlled Trial Investigating the Effects of A 6-Month Low, Regular, or High Dietary Sweet Taste Exposure on Sweet Taste Liking, and Various Outcomes Related to Food Intake and Weight Status.

In the current trial, altering exposure to sweet-tasting foods did not change sweet taste liking, nor other outcomes. These results do not support public health advice to reduce exposure to sweet-tasting foods, independent of other relevant factors such as energy density and food form.

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The influence of hemoglobin measurement error on accuracy of population anemia surveillance: results from mathematical simulations.

Random error (SD inflation ratio) has less influence than systematic error (mean bias) on anemia prevalence estimates. Efforts to reduce mean bias during data collection or through statistical adjustment may have a greater impact on anemia prevalence assessment.

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Thiamine status in Belgian adults assessed by volumetric absorptive microsampling: a nation-wide cross-sectional survey.

Although nearly al Belgian adults met thiamine intake requirements, 11% showed biomarker concentrations indicative of thiamine insufficiency, underscoring the importance of biomarker-based nutritional assessments. This study also demonstrates that at-home VAMS microsampling is a feasible and convenient tool for large-scale biomarker collection.

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Undernutrition or Obesity: Relationship with Long-Term Survival in Children with Acute Lymphoblastic Leukemia in an Upper-Middle Income Country. A multicenter cohort study.

Undernutrition was not associated with long-term survival in pediatric patients with ALL. However, overweight and obesity at diagnosis were associated with relapse and increased mortality, highlighting the importance of addressing these factors through interventions focused on nutritional optimization, especially regarding obesity prevention and management, at or prior diagnosis, to improve outcomes in Mexican children with ALL.

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Inflamm Bowel Dis
CRUCIAL Insights From a Decade Long Retrospective National Audit of Total Abdominal Colectomy Outcomes for Ulcerative Colitis.

This national audit demonstrates low mortality and acceptable morbidity following TAC for UC, with increasing use of laparoscopy over time. The robust, diagnosis-validated data support international standards of care and highlights key predictors of postoperative complications in this population. It identifies elderly, immunosuppressed patients requiring emergency open surgery as the highest risk patient subgroup.

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Efficacy, Safety, and Pharmacokinetics of Golimumab in Children with Moderately-To-Severely Active Ulcerative Colitis: Results from the PURSUIT 2 Study.

ClinicalTrials. gov ID: NCT03596645.

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Real-World Implementation of Treat to Target in Patients With IBD in a Learning Health System: An IBD Qorus Collaborative Study.

Through a QI initiative in a learning health system, rates of intention to TTT increased significantly over 12-months, though overall rates remained low. Assessing patient-, provider- and practice-level barriers and facilitators for successful implementation of a TTT strategy is warranted to improve clinical outcomes.

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Surgical management of small bowel adenocarcinoma in Crohn disease: a multicenter retrospective analysis.

In patients with long-standing CD, SBA is typically an incidental diagnosis made at an advanced stage. While high rates of complete surgical resection are possible, the prognosis remains guarded due to aggressive tumor biology and high recurrence rates. These findings highlight a critical need for improved risk stratification to guide surveillance and for the development of evidence-based adjuvant treatment strategies.

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The Role of Autophagy in Inflammatory Diseases: Challenges and Therapeutic Potential.

Current therapeutic approaches targeting autophagy are reviewed, alongside emerging strategies and their clinical implications. This comprehensive analysis underscores the importance of understanding the multifaceted roles of autophagy in immune regulation, with the aim of advancing therapeutic interventions for inflammatory and cancer-related conditions.

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J Crohns Colitis
Inflammatory Bowel Disease is associated with increased intestinal extrachromosomal circular DNA: an emerging biomarker for IBD type and activity.

Here, we uncover an IBD-specific pattern of eccDNA production from intestinal biopsies. Furthermore, we have identified genic hotspots which characterize active disease. We propose that eccDNA containing specific gene fragments (eg, NRG1 and ZPMF2) could represent a promising new biomarker tool for patients with IBD.

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Treat-to-target optimization of biologic therapy is effective on endoscopic and histologic outcomes in a real-life cohort of ulcerative colitis-the TACTIC-UC study.

In UC patients with quiescent or mild symptoms but active endoscopic inflammation, endoscopy-guided optimization of biologics is effective in achieving deeper inflammatory control, supporting its integration into T2T strategies.

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Liver Transpl
Proceedings of the 30th annual congress of the international liver transplantation society.

The program emphasized collaboration and innovation to advance patient outcomes in liver transplantation. In this report, the ILTS Vanguard Committee summarizes the key proceedings of the congress.

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Pancreas
OGT-mediated O-GlcNAcylation of ATF3 Transcriptionally Activates ACSL1 to Aggravate Ferroptosis in Severe Acute Pancreatitis: ATF3 O-GlcNAcylation Promotes SAP Ferroptosis.

The OGT-mediated O-GlcNAcylation of ATF3 is significantly enhanced, thereby promoting the transcriptional activity of ASCL1 and exacerbating ferroptosis in SAP.

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Pancreatology
Establishment of simple pancreatic ductal adenocarcinoma identification method: S100P measurement in duodenal fluid obtained during upper gastrointestinal endoscopy.

This study demonstrated the utility of the S100P in DF analysis for the early diagnosis of PDAC and clarified potential issues related to sample collections in the actual clinical settings.

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Evolution of the Spatial transcriptomic landscape during the progression of high-grade pancreatic intraductal papillary mucinous neoplasms to invasive cancer.

Our study integrates multiple computational approaches for spatial transcriptomics to identify ELF3/MYC/KLF4 amplifications during IPMN-to-PDAC progression, as well as 7 heterogeneous subclones with functions including hypoxia and EMT, alongside immune-stromal landscape remodeling and tumor-adjacent myofibroblastic CAF enrichment.

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Genomic characterization and prognosis of pancreatic adenosquamous carcinoma.

Pathway enrichment analysis indicated that STK11 mutations, high tumor mutational burden (TMB-H), APC deletion, TERT/RICTOR amplification, and chromosomal instability (CIN-H) were significantly associated with altered pathways. Additionally, we confirmed the prognostic value of our PASC-specific signature through validation in an independent cohort of pancreatic ductal adenocarcinoma patients.

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ORM2 alleviates pancreatic fibrosis in chronic pancreatitis by modulating autophagy via ZG16.

ORM2 alleviates pancreatic fibrosis in CP by binding to ZG16 and inhibiting autophagy-driven PSC activation. These findings identify ORM2 as a promising therapeutic agent for pancreatic fibrosis.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Am J Clin Nutr
Validation of food intake biomarkers is key to advancing the potential use in assessment of dietary intake.

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Inflamm Bowel Dis
B Cell Dysregulation in IBD: From Pathophysiology to Therapeutic Targeting.

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J Crohns Colitis
Towards tailored surveillance strategies in inflammatory bowel disease: still a long way to go.

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Pancreatology
Cannabis use in chronic pancreatitis: A narrative review.

The existing evidence surrounding cannabis use in chronic pancreatitis is limited and mostly low-quality. Further investigation is warranted to explore whether medical cannabis could represent an effective therapy for patients with chronic pancreatitis.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

J Crohns Colitis
Revisiting Patient Stratification and Inflammatory Assessment in Ulcerative Colitis-Associated Colorectal Cancer.

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Liver Transpl
Correlation or causation? Addressing the gap between oral dysbiosis and liver transplant outcomes.

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The understudied complication of MASLD: Does exercise offer neuroprotection?

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Pancreas
Long-term Follow-up of Spontaneous Resolution of a Pancreatic Arteriovenous Malformation.

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Pancreatology
The Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) 10 years of past accomplishments and looking forward to the next 5 years of the Chronic Pancreatitis Clinical Research Consortium (CPCRC).

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Letters&Replies

Letters to the editors and authors’ replies

Am J Clin Nutr
Queries and Comment to the Article by Ichikawa et al.

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Pancreatology
Comment on "Effect of albumin infusion in patients with predicted severe acute pancreatitis: A randomized controlled trial".

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Comment on "Focal pancreatic parenchymal atrophy could be a precursor of pancreatic cancer" (Kikuyama et al., Pancreatology 2025).

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Response to the Letter to Editor: Strengths and methodological considerations for predicting post-pancreatectomy acute pancreatitis.

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Response to the letter to the editor regarding "Predictors of acute pancreatitis in patients treated with GLP-1 receptor agonists for weight management".

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